When was the last time you played the Endar Spire prior to having this issue?
Where exactly does the game crash( As Trask is saying his line, as he's moving, when Bandon shows up, when Trask is in the room, as/after the door's closing, .etc)?
Have you looked at the Anti-Aliasing, Anisotropic Filtering, Soft Shadows, Shadows, Grass, and Frame Buffer Effects?
Have you changed your hardware since you last restarted the game (before this crashing business)?
And in the future, please use the layout from this post as a guide for posting and please keep just one thread for all of your compatibility issues.