Hi! I play both Kotor games on my MacBook and I am able to install mods that use tslpatcher with ease, using winebottler, despite being terrible with computers, and relatively new to my MacBook. I can pm you how I do my whole process (in depth plus screenshots) for using tslpatcher if you like because it took me a lot of figuring out and research to be able to get it right, and I'd be happy to help and explain for someone else, and it sucks that you would have to miss out on some amazing mods that use the tslpatcher. I'd be happy to do this for anyone else as well, who has issues using tslpatcher mods on Mac.
I do however only use the steam workshop version of TSLRCM. Everything else I drop into steam workshop's tslrcm override folder. I'm not sure if having multiple steam workshop installs is the issue with tlspatcher not working - I could imagine though that it is an issue, that the patcher has to sort through multiple override folders. And I'm soon going to do a clean reinstall of my Kotor 2, to use the installer version of tslrcm, just to be safe with mods I download using tslpatcher (though I have downloaded and tested tslpatcher mods using my current mod setup so I know as long as you have only one workshop override it definitely works).