Only thing I'd recommend for a first playthrough is maybe just a bug-fix here and there. Personally, I try to keep my first run of a game as vanilla as possible.
Took a loot at the Nexus page, and I'd have to recommend "Yukichigai Unofficial Patch" or "YUP" for short. It's just strictly bug-fixes, and doesn't require anything extra, like the New Vegas Script Extender. Last update was fairly recently too, on June 16th.
