I've played through TSL many times with TSLRCM 1.8.5 + Handmaiden4Females and they are compatible but there is a small problem i find i get when installing other mods that change the Handmaiden.dlg and the globalcat.rar files from the Handmaiden4Females mod, so i always save my game before speaking to the Handmaiden, if i don't get the cutscene with Atris talking to the Handmaidensisters i know i hav'nt recruited the Handmaiden, i then exit the game fully and extract these 2 files from the Handmaiden4Females folder into the override folder, overwriting if asked (Handmaiden.dlg + globalcat.rar) then i load my save game and chat to the Handmaiden choosing the correct dialog, run to the Ebon Hawk and watch the cutscene with Atris, i now have the Handmaiden. Not sure if this is the right way to go about solving this but it works for me.