I have the same issue. Lashowe is invincible. I am guessing that she is invincible so that the 3 creatures can't hurt her, but god mod stays afterwards and I can't get the holocron from her. The only two mods that could be causing this are Restoration 1.2 and the comprehensive kotor bug fix collection.
I have a similar problem, except that I can't play the 4th one, droid. Basically, it doesn't exist, it has never been created. Those that have played against droid, where exactly is it located?