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Yes, it's heuristic flagging of the Python exe that gets extracted into a temp directory to run the code under the hood: https://www.virustotal.com/gui/file/1028c8f33ba05e3ba416b823883f970f53f3157052ab9a466031355152da4717?nocache=1 Detects the image load of "Python Core" by a non-Python process. This might be indicative of a Python script bundled with Py2Exe It's a problem with all versions of HoloPatcher and no-name AV packages. It won't be solved until/unless HP migrates away from Python.

The easiest would be to use Kotor Tool and K-GFF editor to modify the .UTI file. Here's an in-depth tutorial.