Finished my first playthrough with TSLRCM! Went with Male, LS(mostly), Sentinel/Watchman, and loved it so much more than my playthrough without TSLRCM. It still left a few questions and concerns. I don't know how to do that spoiler window thing that Fins did, so old school:
**SPOILERS**
1) What happened to Bao-dur? I got to the return to Telos bit, and he just up and disappears. and the only thing that's said is "Yeah, where did he go? him and HK-47?" HK had, of course, gone to the Factory. Bao-dur, well... I got nothing.
2) Why did the game insist that my character had a relationship with Visas? It shoved into a relationship with her on my first playthrough, and I decided to run with it that time, but this time around I tried to foster a relationship with the Handmaiden. I treated Visas with indifference at best, and at the end the game still went on as if I had a relationship with her.
3) During the Malachor sequence, there is a bunch of talk about whether or not the General will order the use of the Shadow Mass Generator. Or is it the Mass Shadow Generator? I forget. which is kind of the point. There is no choice given, no actual mention of the Weapon prior to the sequence. There is some innuendo that "something" happened at Malachor, but no specifics until the end, and then it is glossed over.
4) On M4-78, why does Vash's apprentice get killed? I understand the death of Vash (though I hate it, she had potential, and I liked her more than any of the other Masters). But after you fix M4-78, there is no way to justify the death of her apprentice, story-wise.
That covers the stuff i can think of for the moment (kind of exhausted right now). Again, overall, I loved it, just a couple of things nagging at my OCD-addled brain.