I have many mods running with TSLRCM 1.6 + Nar Shadaa Fix + updated Dialog without any problems each play through. I also have Squ1zZy Resolution Patcher set at 1280x800 and HUD Fix.
Apart form usual mods like KotOR II The Sith Lords Movies Patch + Music Patch and Prolog, Peragus And Harbinger Correction Mod v.1.1 I use:
Achilles Mira Makeover
Any Spell Mod
Ascension Feat v1.0
Bao Dur Charged Armor
Bao-Dur Shader Fix
Better Male Bodies
Coruscant Sky Box Retexture
Cyan Lightsaber Fix
Cybernetic Gear
Dantooine Hi-Res Retexture
Disciple Improvement
Droid Enhancement
Dxun - Ravager Reskin
Enhanced Merchants
Expanded Workbench Revised v2.02
Extra Starport Visas Mod
Fixed Mandalorian Banners
Force Fashion including sv?sh'es Collar Fix and Master Robe Skins
Goto's Yacht Window Upgrade
High-Res Footlocker
High-Res Ithorians Approved v1.0
High-Res Lightning Sith Edition
HK Droid Items v1.3
Increased Attributes And Skills
Infinite Force Powers v1.0
Korriban Hi-Res Retexture
Blood Rose Lightsaber Hilt
Loading Screen Revamp v1.0
Mandalorian Worn Out Armour
Miner Uniform Reskin
Modified Items
More Feats
More Realistic Visual Effects
Nar Shaddaa Sky Box Retexture
Neutral Side Mod
New Force Crush
New NPC Portraits
New Workbench Upgrades v1.5
Nihilus And Visas In-Game Cutscene
Non-Starving Female Models but only Dancer's Outfit
Party XP Bug Fix
Peragus Mining Shield Fix
PFHC06 Female Head Fix
Prequel Sabers
Prestige Classes Bonus v1.0
Restored Doors And Rooms Pt.1 and Pt.2
Revan Model Without Cape
Rubat Crystal Fix
Sion Arrival To Peragus Fix v2.0
Telos Crash Movie Fix
Twin Suns Outfit For Female PC
VP Modules Tweak
Weapon Finesse Icon Fix
Workbench Reworked
I run Windows XP Home Edition and Service Pack 3.