So this just started happening to me. The only mods I have are TSLRCM and the M4-78 Enhancement project. I got through all of the other planets just fine without any issues until now. It happened after I talked with the guy to free the doctor on Iziz. My save game won't even load, and the game crashes.
These are my system specs:
Windows 7 Home Premium 64 bit
AMD Athlon II X2 220 Processor 2.80 GHZ (5 GHZ total since there is another one on top of the other)
3 GB of Ram
GeForce 9400 GT 1 GB Video Card (upgrading soon)
Like I have mentioned I've had no issues up until now. I have a no-cd crack in place of the exe, but have backed up the original exe file. I'm not sure what I should do from here, thought about putting compatibility mode on, and see what happens from there.